Rheumatoid Arthritis (RA) is an autoimmune disease characterized by erosive arthritis that can occur at any age. The basic pathological manifestations of RA are synovitis, pannus formation, and gradually the destruction of articular cartilage and bone, eventually leading to joint deformity and loss of function, which can be complicated by lung diseases, cardiovascular diseases, malignant tumors and depression.

According to the 2010 ACR/EULAR Rheumatoid Arthritis Classification Criteria, RF and Anti-CCP were included in the diagnosis and classification criteria. In 2021, Chinese Expert Consensus on the Clinical Application of Autoantibody Detection related to Rheumatoid Arthritis recommended the joint testing of Anti-CCP and RF serum biomarkers to improve the diagnostic sensitivity of RA.It can also be used to evaluate arthritis activity, treatment effect, and degree of joint damage, and to predict the risk of developing arthritis in patients with arthralgia in recent years and to guide the development of treatment plans.