The Nervous System is the most complex system in the human body, expressing the largest number of genes, the largest number of cell types, complex fiber connections, and the most complex developmental processes. Therefore, the types of neurological diseases are also the largest, and their clinical manifestations are usually complex and diverse with hidden onset, which is easy to lead to misdiagnosis or delayed treatment, and even permanent neurological function defects, bringing heavy burdens to families and society. Therefore, early diagnosis, treatment and long-term monitoring of nervous system diseases are very important, and the markers related to nervous system are crucial for early diagnosis, differential diagnosis and efficacy monitoring of diseases.